My husband called Neosporin zit cream for men. I've always told him it was not the case and now I have the facts explaining why. Some people, like my husband, think that because Neosporin works as an antibiotic for cuts, it'll also kill the bacteria that causes acne. Not so much says Dr. Doris Day, a New York City-based dermatologist. Day claims that while the ointment clogs pores, it has no effect on acne-causing bacteria and can't even reach the base of the skin's follicle, where acne actually forms.