Neurofibromatosis 2
Overview
Illustrations
HEALTH GUIDE REFERENCE FROM A.D.A.M
Definition
Neurofibromatosis 2 (NF2) is a genetic disorder in which tumors form on the nerves of the brain and spine (the central nervous system).
See also: Neurofibromatosis 1 (NF1)
Alternative Names
NF2; Bilateral acoustic neurofibromatosis; Central bilateral acoustic NF
Causes, incidence, and risk factors
NF2 is passed down through families in an autosomal dominant fashion. This means that if one parent has NF2, any child of that parent has a 50-50 chance of having it.
The main risk factor is having a family history of the condition.
Symptoms
Symptoms of NF2 include:
- Balance problems
- Cataracts at a young age
- Changes in vision
- Coffee-colored marks on the skin
- Facial weakness
- Headaches
- Hearing loss
- Ringing and noises in the ears
Signs and tests
Signs include:
- Brain and spinal tumors
- Hearing-related (acoustic) tumors
- Skin tumors
Tests include:
- Genetic testing
- Medical history
- MRI
- Physical examination
Treatment
Most patients need surgery to remove tumors. Tumors also can be treated with radiation.
Support Groups
For information and support, visit www.nf.org.
Review Date: 10/25/2007
Reviewed By: Chad Haldeman-Englert, M.D., Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
Reviewed By: Chad Haldeman-Englert, M.D., Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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